He was recently hospitalized in Las Vegas due to complication from the blood disorder sickle cell anemia, according to a statement released by his publicist.
His cause of death is as of yet unconfirmed.
However, it was under the name Mobb Deep that they became one of the signature acts of 1990s NY hip-hop, perhaps best evidenced by the song "Shook Ones (Part II)".
The New York City native performed Saturday with his partner, Havoc, as a part of the "Art of Rap" tour, along with Ghostface Killah, Onyx, KRS-One and Ice-T, among others.
Musicians around the world have paid tribute to American rapper Prodigy who has died aged 42.
Albert Johnson, better known as rapper Prodigy of the hip hop duo Mobb Deep, died Tuesday. "We would like to thank everyone for respecting the family's privacy at this time", the statement reads. The book, "commissary kitchen: my infamous prison cookbook", was released on Infamous, Prodigy's own imprint at Brooklyn-based Akashic Books. And Prodigy remained musically prolific, releasing multiple solo projects including last year's Untitled EP. The news was broken on Twitter by fellow New York MC Nas and later confirmed by the group's PR agency.
"It made me realize the gravity, the reality of having everything taken from you".
He said of his children: "I just tell them, you know, it was awful".