The dedication comes on Presidents' Day and as year-long celebrations kick off in recognition of the 100 anniversary of the 35 President's birth.
USPS announced the stamp in early January, adding that it will be available for purchase at post offices across the country on February 21.
Kennedy, the 35 USA president, was born May 29, 1917.
A 1960s photograph of Kennedy from the campaign trail appears on the stamp.
The separate artwork accompanying the stamp is the official presidential portrait of Kennedy, painted posthumously at the request of former first lady Jacqueline Kennedy in 1970.
Representatives of the Kennedy family and members of Congress are expected to attend the event, which also provides an opportunity for children to write letters to the current president, Donald Trump. It will be followed by a Presidents Day family festival at the library, which will have any entry fee. On Jan. 22, the price of stamps increased from 47 cents to 49 cents.