The accident occurred shortly before 7 p.m. Friday in the southern town of Oswiecim, Szydlo's hometown.
The Prime Minister was in a convoy travelling along a main road when a Fiat 500 from a nearby street drove into her vehicle.
The 53-year-old was taken to hospital after a 20-year-0ld man crashed into her government convoy in Oswiecim, near Krakow.
Polish Prime Minister Beata Szydlo was injured in a vehicle collision in the south Polish city of Oswiecim late on Friday, Polish Press Agency (PAP) reported.
A government spokesperson reportedly told the media outlet that Szydlo suffered bruises in the accident but was taken to the hospital as a precaution for routine checks.
The official said Szydlo suffered bruising.
However, two Polish officials were injured in the crash. Two security agents including Szydlo's driver were also injured, one of them suffering serious leg injuries. It is the town where Nazi Germany ran the death camp in occupied Poland during World War II and today is the site of a memorial and museum that draws large numbers of visitors.
Polish President Andrzej Duda and Defence Minister Antoni Macierewicz have also been involved in recent vehicle accidents, though without injury.
Meanwhile, Interior Minister Mariusz Blaszczak called an urgent meeting with top BOR officials to discuss the situation.
In November, Ms Szydlo's motorcade was involved in an accident in Israel.
Separately, Defence Minister Antoni Macierewicz escaped uninjured from an eight-car collision in January.